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NEUROLOGIC UNIT

Director: Marco Onofrj
Tel 0871-5411
E-Mail onofrj@unich.it
Clinical and experimental protocols.

Principal Research Projects:
- Organization and modulation of the visual pathway;
- Diagnostic techniques. Clinical Neurophthalmology;
- Mechanism and formation of demielinating lesions, Diagnostic techniques. Multiple Sclerosis Optic Neuritis;
- Cerebral activity during attentional and memory, relation with state of consciousness (coma and locked-in syndrome);
- Therapy of rare Movement Disorders and tremors;
- Epilepsy Therapy;
- Parkinson’s Disease. Diagnostic techniques, models and therapy;
- Alzheimer’s Disease . Diagnostic techniques, therapy;
- Lewy Body Dementia . Diagnostic techniques, therapy;
- Sleep disturbances;
- Staminal Cells;
- Behavioural Disturbances, psychosis, hallucinations in course of neurodegenerative disorders;
- characterization and therapy;
- Axial dystonias in parkinsonism;
- Lesional Mechanism and neurodegenerative models. New therapeutic hypotheses.

Research activity in CeSI:
- High Density Electroencephalography (High Density EEG), Functional MRI;
- Evaluation of executive frontal functions, orientation, intelligence;
- New farmacological studies: Parkinson’s Disease, Alzheimer’s Disease, Neck Dystonia, Psychosis in PD;

Farmacological studies:
- Completed studies: Amisulpride, Apomorfin, Botox, Cabergoline, CHF 1512, Citidine, Donepezil, Duodopa, Entacapone, E2007, Felbamate, FP0011, FP0153, Galantamine, Istradefiline, Lamotrigine, Levitiracetam, Lisuride, L-Threo Dops, Melperone, Nicergoline, Paroxetine, Pergolide, Pramipexole, Ralfinamide, Rasageline, Rivastigmine, Ropinirole, Rosiglitazone, Safinamide, Sarizotan, SCH 420814, SLV308, Stalevo, TCH 346, Tolcapone, Topimarato.

- Ongoing studies : Stalevo (Novartis) PD moderate; Pramipexole (Boehringer-Ingelheim) PD-depression ; Ropinirolo CR (GSK) PD de novo; Pramipexole CR (Boehringer-Ingelheim) PD with fluctuations and off state; Melperone (Ovation) psychosis in PD; SCH 420814 (Schering-Plough) PD with fluctuations and off state; SLV308 (Solvay) PD de novo; Rosiglitazione (GSK) AD moderate sever; Rotigotina (Schwarz Pharma) patch PD morning akinesia; Safinamide (Newron) PD with fluctuations and off state; Lisuride (Axxonis) PD with fluctuations and off state; FP0011/ FP0153 (Faust) PD de novo; E2007 (Esai) PD with fluctuations and off state; 2020 (Esai) AD PR moderate; Duodopa (Solvay) PD with fluctuations and off state.